反应详情

温度

90 °C

A mixture of methyl (4-fluorophenyl)(oxo)acetate (1.1 g, 0.0059 mol), thiosemicarbazide (0.54 g, 0.0059 mol) in water (10 mL) was heated at reflux for 15 min. Then methanol (10 mL) was added, followed by potassium hydroxide (0.43 g, 0.0077 mol). The mixture was stirred at 90° C. overnight. After cooling, methyl iodide (4 mL, 0.06 mol) was added. The mixture was stirred at RT for 30 min. The precipitate formed was collected by filtration, washed with ether, and dried under high vacuum to give the desired product (1.2 g, 77%). Analytical LCMS: (M+H)+=238.1.

1. temperaturewas heated
2. temperatureat reflux for 15 min
3. temperatureAfter cooling
4. stirringThe mixture was stirred at RT for 30 min
5. customThe precipitate formed
6. filtrationwas collected by filtration
7. washwashed with ether
8. customdried under high vacuum