Sodium Bicarbonate → HCID 178495390, compound

Participants

Reaction Conditions

Reaction Steps

100 g of rabeprazole sodium salt (amorphous) is dissolved at approximately 25° C. in 450 ml of ethyl acetate. The solution is kept at approximately 25° C. and 8 ml of sodium bicarbonate saturated solution is added. The mixture is seeded with a small amount of Form γ, then kept under stirring at approximately 25° C. for 25 hours. The resulting white solid is filtered by suction, washed with 100 ml of ethyl acetate and dried under vacuum at 45° C. The resulting product has an XRPD spectrum substantially as reported in FIG. 1 and a DSC thermogram substantially as shown in FIG. 2, which prove that the compound is crystalline. The compound water content determined according to Karl Fischer is approximately 4.5-4.7%.

Provenance & Evidence