反应详情

温度

50 °C

To a solution of methyl 3-phenylpyridine-2-carboxylate (61.0 g, 286 mmol) in absolute ethanol was added potassium hydroxide (32.0 g, 572 mmol). After stirring at 50° C. for 2 h, the reaction mixture was cooled and adjusted to pH ˜7.5 with 1M phosphoric acid. The mixture was diluted with water (1 L) and extracted with EtOAc (2×600 ml). The organic portion was dried over magnesium sulfate, filtered, and concentrated in vacuo to yield 3-phenylpyridine-2-carboxylic acid as a solid (54.7 g).

1. temperaturethe reaction mixture was cooled
2. extractionextracted with EtOAc (2×600 ml)
3. dry with materialThe organic portion was dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo