Benzylamine → HCID 66811489, compound

Participants

Reaction Steps

To a solution of 1-(tert-butoxycarbonyl)-3-phenylpiperidine-2-carboxylic acid (1.03 g, 3.36 mmol) in DMF (5 ml) were added benzyl amine (0.4 ml, 3.70 mmol), 1-hydroxybenzotriazole (567 mg, 3.70 mmol), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (949 mg, 4.70 mmol). The reaction was adjusted to pH 7 with the addition of diisopropylethylamine and allowed to stir for 1 h. The reaction mixture was diluted with EtOAc, washed with saturated sodium bicarbonate (3×) and brine (2×), dried over sodium sulfate, filtered, and concentrated in vacuo to yield tert-butyl 2-[(benzylamino)carbonyl]-3-phenylpiperidine-1-carboxylate (100%).

Provenance & Evidence