Hydrochloric Acid → HCID 66811551, compound

Participants

Reaction Steps

To a solution of 1-phenyl-N-[(3-phenylpiperidin-2-yl)methyl]methanamine (101 mg, 0.359 mmol) in methanol (5 ml) were added 4M HCl in dioxane (0.090 ml, 0.359 mmol) and palladium hydroxide (28.9 mg, 0.036 mmol). The reaction mixture was charged with 1 atm hydrogen gas and allowed to stir for 18 h. The reaction mixture was filtered through celite, and to the filtrate was added 4M HCl in dioxane (0.090 ml, 0.359 mmol). The reaction was allowed to stir for 1 h and concentrated in vacuo to yield 2-(ammoniomethyl)-3-phenylpiperidinium dichloride (61%). LCMS (M+H)=191.0.

Provenance & Evidence