Imidazole → HCID 66811607, compound

Participants

Reaction Steps

To a solution of tert-butyl 2-{[2-({1-[(benzyloxy)carbonyl]azetidin-3-yl}carbonyl)hydrazino]carbonyl}-3-phenylpiperidine-1-carboxylate (235 mg, 0.44 mmol) in dichloromethane (4 ml) at 0° C. were added imidazole (71.6 mg, 1.05 mmol), polystyrene bound triphenyl phosphine (471 mg, 0.96 mmol, 2.04 g/mmol), and carbon tetrabromide (320 mg, 0.96 mmol). The reaction was warmed to rt and allowed to stir for 18 h. The reaction mixture was filtered and rinsed with dichloromethane. The filtrate was concentrated to give an oil. The crude material was purified via flash chromatography (silica, 0-35% EtOAc/hexanes) to yield tert-butyl 2-(5-{1-[(benzyloxy)carbonyl]azetidin-3-yl}-1,3,4-oxadiazol-2-yl)-3-phenylpiperidine-1-carboxylate (96%) as a colorless oil.

Provenance & Evidence