Hydrochloric Acid → HCID 66811572, compound

Participants

Reaction Steps

To a solution of methyl (4-butyl-2,3-dioxopiperazin-1-yl)(phenyl)acetate (2.5 g, 9.1 mmol) in 1:1 methanol/THF (40 ml) was added 1N LiOH (18.2 ml, 18.2 mmol). The reaction was warmed to rt and allowed to stir for 18 h. The reaction mixture was cooled to 0° C., adjusted to pH 2 with conc HCl, and concentrated in vacuo. The residue was dissolved in EtOAc, washed with brine, dried over sodium sulfate, filtered, and concentrated to yield (4-butyl-2,3-dioxopiperazin-1-yl)(phenyl)acetic acid (100%).

Provenance & Evidence