Triethylamine → HCID 17751589, compound

Participants

Reaction Steps

A mixture of 1-[4-amino-5-(4-aminophenyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]ethanone (50.0 mg, 0.19 mmol), phenyl[6-(trifluoromethyl)pyridin-2-yl]carbamate (105.6 mg, 0.37 mmol), and triethylamine (0.10 mL, 0.75 mmol) in DMF (2 mL) was stirred overnight resulting in formation of a precipitate. The mixture was diluted with DMSO (1 mL) and then the solid was collected by filtration, washed with MeOH, and air-dried to give 53.0 mg (62%) of the title compound. 1H-NMR (DMSO-d6) δ 9.87 (s, 1 H), 9.71 (s, 1 H), 9.60 (d, J=3.2 Hz, 1H), 8.34 (d, J=3.3, 1 H), 8.10 (s, 1 H), 8.04-8.02 (m, 4 H), 7.76 (s, 1 H), 7.59 (d, J=8.7 Hz, 2 H), 7.52-7.50 (m, 1 H), 2.64 (s, 3 H); MS [M+H]+=456.1; LCMS RT=3.25 min.

Provenance & Evidence