Triethylamine → HCID 59232202, compound

Participants

Reaction Steps

A solution of [4-amino-5-(4-aminophenyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methanol (170.0 mg, 0.67 mmol), phenyl[6-(trifluoromethyl)pyridin-2-yl]carbamate (281.9 mg, 1.00 mmol), and triethylamine (0.46 mL, 1.33 mmol) in DMF (5 mL) was stirred at rt for 3 d. The crude reaction mixture was purified directly by HPLC using a gradient of 20-90% MeCN in water to yield 21.1 mg (7%) of the title compound. 1H-NMR (DMSO-d6) 9.89 (bs, 1 H), 9.72 (bs, 1 H), 8.05-7.98 (m, 2 H), 7.89 (s, 1 H), 7.57 (d, J=8.6 Hz, 2 H), 7.51-7.49 (m, 1 H), 7.40 (d, J=8.6 Hz, 1 H), 6.64 (s, 1 H), 5.19 (t, J=5.7 Hz, 1 H), 4.74 (d, J=5.6 Hz, 3 H); MS [M+H]+=444.1; LCMS RT=2.63 min.

Provenance & Evidence