HCID 59232202, compound → HCID 59232186, compound

Participants

Reaction Steps

To a suspension of Example 105 (14.7 mg, 0.033 mmol) in THF (3 mL) was added 3,3,3-triacetoxy-3-iodophthalide (42.2 mg, 0.10 mmol). The mixture was stirred at rt under nitrogen for 4 d. The solvent was evaporated under reduced pressure. The residue was dissolved in DMF and purified by HPLC using a gradient of 20-90% MeCN in water to yield 6.0 mg (41%) of the title compound. 1H-NMR (DMSO-d6) 10.34 (s, 1 H), 9.90 (bs, 1 H), 9.75 (bs, 1 H), 8.15 (s, 1 H), 8.06-7.99 (m, 2 H), 7.59 (d, J=8.6, 2 H), 7.51 (dd, J=7.0, 1.1, Hz, 1 H), 7.46 (d, J=8.5 Hz, 2 H), 7.25 (s, 1 H); MS [M+H]+=442.1; LCMS RT=3.29 min.

Provenance & Evidence