Ethanamine, 2,2,2-trifluoro- → HCID 59404973, compound

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Reaction Steps

To a suspension of N-[4-(4-amino-7-formylpyrrolo[2,1-f][1,2,4]triazin-5-yl)phenyl]-N′-[6-(trifluoromethyl)pyridin-2-yl]urea (5.0 mg, 0.011 mmol) in 1,2-dichloroethane (2 mL) was added 2,2,2-trifluoroethylamine (11.2 mg, 0.11 mmol), followed by sodium triacetoxyborohydride (24.0 mg, 0.11 mg). The mixture was stirred at rt under nitrogen for 4 d. The solvent was evaporated under reduced pressure. The residue was dissolved in DMF and purified by HPLC using a gradient of 20-90% MeCN in water to yield 2.1 mg (35%) of the title compound. 1H-NMR (DMSO-d6) 9.95 (bs, 1 H), 9.79 (bs, 1 H), 8.05-7.99 (m, 2 H), 7.90 (s, 1 H), 7.57 (d, J=8.6, 2 H), 7.50 (dd, J=6.4, 1.7, Hz, 1 H), 7.40 (d, J=8.6 Hz, 2 H), 6.66 (s, 1 H), 4.07 (d, J=6.8 Hz, 2 H), 3.30-3.23 (m, 2 H), 2.92-2.85 (m, 1 H); MS [M+H]+=525.1; LCMS RT=2.91 min.

Provenance & Evidence