Water → HCID 59232072, compound

Participants

Reaction Steps

To a suspension of 1-{4-[4-amino-7-(2-hydroxyethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea (1.28 g, 2.60 mmol) in anhyrous THF (32 ml) at 0° C. was added CBr4 (1.03 g, 3.1 mmol)) followed by Ph3P (0.75 g, 2.9 mmol) and the reaction was stirred at rt for 24 h. The reaction mixture was poured into H2O (100 ml) and extracted with 150 ml EtOAc. The organic layer was washed with satd. aq NaHCO3, brine and dried over Na2SO4 and was concentrated to give a yellow oil (1.6 g), which was used without further purification. MS [M+H]+=557.2; LCMS RT=3.27 min.

Provenance & Evidence