Hydrochloric Acid → HCID 59232196, compound

Participants

Reaction Steps

To a suspension of 1-{4-[4-amino-7-(4-{[tert-butyl(dimethyl)silyl]oxy}butyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl}-3-[2-fluoro-5-(trifluoromethyl)-phenyl]urea in 3 ml 95:5 EtOH/H2O was added 30 μL conc. HCl. for 30 min. The reaction mixture was quenched with 5 ml saturated NaHCO3. After the solvent EtOH was evaporated, the crude was extracted with EtOAc (3×). The resulting crude organic was dried and concentrated and trituated with EtOAc and hexane to give 115 mg of pure title compound as a white solid. MS [M+H]+=521.2; LC/MS RT=2.94 min.

Provenance & Evidence