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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1099373Generated: November 2, 2026

Water → 4-Methoxy-5-methyl-2-(4-nitro-phenoxy)-indan-1-one

https://huagongshe.com/reaction/1099373

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
Reactant4-NitrophenolHCID 980—
ReactantSodiumHCID 5360545—
Reactant2-Bromo-4-methoxy-5-methyl-indan-1-oneHCID 66812711—
SolventDimethylformamideHCID 6228—
Product4-Methoxy-5-methyl-2-(4-nitro-phenoxy)-indan-1-oneHCID 6681309573.7%

Reaction Conditions

Temperature26.5 °C

Reaction Steps

To a stirred solution of 2-Bromo-4-methoxy-5-methyl-indan-1-one (2.0 gm, 0.0078 mole) in Dimethylformamide (15 ml), added Sodium salt of 4-Nitrophenol (1.27 gm, 0.0078 mole) at 10-15° C. After 2 hours stirring at 25-28° C., reaction mixture was poured into water (50 ml). The separated solid was filtered, washed with hexane and dried under vacuum to give 1.8 gm of desired product as a solid

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08143424B2
Source datasetuspto-grants-2012_03
ORD IDord-f0b529860c744ac0a002fdbb7ddd39e5
Source noteuspto-grants-2012_03