HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → (2R)-N,N-Dibenzyl-8-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 2773987 | — |
| Reactant | (2R)-N,N-dibenzyl-8-bromo-1,2,3,4-tetrahydronaphthalen-2-amine | HCID 22082960 | — |
| Product | (2R)-N,N-Dibenzyl-8-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine | HCID 25114041 | 96% |
Reaction Steps
The title compound was synthesized as described for Intermediate example I-2 in 96% yield, starting from 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole and (2R)-N,N-dibenzyl-8-bromo-1,2,3,4-tetrahydronaphthalen-2-amine: MS (ESI) m/z 408[M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143408B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-f4994f76844d414d80635ebbb9fc3b21 |
| Source note | uspto-grants-2012_03 |