3,5-Dimethylpyrazole-4-boronic acid, pinacol ester → (2R)-N,N-Dibenzyl-8-(3,5-dimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine

Participants

Reaction Steps

The title compound was synthesized as described for Intermediate example I-4 in 58% yield, starting from 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1 H-pyrazole and (2R)-N,N-dibenzyl-8-bromo-1,2,3,4-tetrahydronaphthalen-2-amine (described in WO9905134A1): MS (ESI) m/z 422[M+H+].

Provenance & Evidence