HuagongsheHuagongshe Chemistry Print Report · For research reference only
(6-Methoxypyridin-3-yl)boronic acid → (3S)-N,N-dibenzyl-5-(6-methoxypyridin-3-yl)chroman-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (6-Methoxypyridin-3-yl)boronic acid | HCID 2734368 | — |
| Reactant | (3S)-3-(Dibenzylamino)-3,4-dihydro-2H-chromen-5-yl trifluoromethanesulfonate | HCID 25053925 | — |
| Product | (3S)-N,N-dibenzyl-5-(6-methoxypyridin-3-yl)chroman-3-amine | HCID 25114481 | 84% |
Reaction Steps
The title compound was synthesized as described for Intermediate example I-2 in 84% yield, starting from 2-methoxy-5-pyridineboronic acid (1.7 equiv) and (3S)-3-(dibenzylamino)-3,4-dihydro-2H-chromen-5-yl trifluoromethanesulfonate; MS (ESI) m/z 437[M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143408B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-f5f196c9e56b4f419681ab0c1fcb81ca |
| Source note | uspto-grants-2012_03 |