(2-Methoxypyridin-3-yl)boronic acid → HCID 25114690, compound

Participants

Reaction Steps

The title compound was synthesized as described for Intermediate example I-2 in 93% yield, starting from 2-methoxypyridine-3-boronic acid and (3S)-3-(dibenzylamino)-3,4-dihydro-2H-chromen-5-yl trifluoromethanesulfonate. The reaction mixture was irradiated in a microwave at 150° C. for 1 h; 1H NMR (400 MHz, DMSO-d6) δ ppm 7.52 (dd, 1 H), 7.25-7.34 (m, 9 H), 7.16-7.24 (m, 2 H), 7.04-7.14 (m, 2 H), 6.76 (d, 1 H), 6.68 (d, 1 H), 4.25-4.35 (m, 1 H), 4.05 (t, 1 H), 3.80 (s, 3 H), 3.55-3.70 (m, 4 H), 2.93-3.04 (m, 1 H), 2.55-2.84 (m, 1 H), 2.27-2.38 (m, 1 H); MS (ESI) m/z 437[M+H+].

Provenance & Evidence