(3S)-3-(Dibenzylamino)-3,4-dihydro-2H-chromen-5-yl trifluoromethanesulfonate → (3S)-N,N-dibenzyl-5-(5-fluoro-6-methoxypyridin-3-yl)chroman-3-amine

Beteiligte Stoffe

Reaktionsschritte

The title compound was synthesized as described for Intermediate example I-2 in 71% yield, starting from 5-fluoro-6-methoxypyridin-3-ylboronic acid (1.7 equiv) and (3S)-3-(dibenzylamino)-3,4-dihydro-2H-chromen-5-yl trifluoromethanesulfonate (1 equiv): 1H NMR (400 MHz, DMSO-d6) δ ppm 7.96 (d, 1 H), 7.73 (dd, 1 H), 7.23-7.37 (m, 8 H), 7.06-7.22 (m, 3 H), 6.78 (dd, 2 H), 4.34 (d, 1 H), 3.92-4.08 (m, 4 H), 3.60-3.79 (m, 4 H), 3.18-3.30 (m, 1 H), 2.89-3.10 (m, 2 H); MS (ESI) m/z 455[M+H+].

Herkunft & Nachweise