(6-Fluoro-5-methylpyridin-3-yl)boronic acid → HCID 25114913, compound

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Reaction Steps

The title compound was synthesized as described for Intermediate example I-2 in 79% yield, starting from 6-fluoro-5-methylpyridin-3-ylboronic acid (1.7 equiv) and (3S)-3-(dibenzylamino)-3,4-dihydro-2H-chromen-5-yl trifluoromethanesulfonate: 1H NMR (400 MHz, CDCl3) δ ppm 7.98 (s, 1 H), 7.50 (dd, 1 H), 7.28-7.36 (m, 8 H), 7.17-7.26 (m, 2 H), 7.14 (t, 1 H), 6.84 (d, 1 H), 6.74 (d, 1 H), 4.32-4.42 (m, 1 H), 4.03 (t, 1 H), 3.65-3.76 (m, 4 H), 3.11-3.25 (m, 1 H), 2.73-2.85 (m, 1 H), 2.61 (dd, 1 H), 2.36 (s, 3 H); MS (ESI) m/z 439[M+H+].

Provenance & Evidence