HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine hydrochloride → 5-bromo-2-methoxy-N-methylnicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine hydrochloride | HCID 6364545 | — |
| Reactant | 5-Bromo-2-methoxypyridine-3-carboxylic acid | HCID 14371728 | — |
| Product | 5-bromo-2-methoxy-N-methylnicotinamide | HCID 25114918 | 43% |
Reaction Steps
The title compound was synthesized as described for Intermediate example I-36 in 43% yield, starting from 5-bromo-2-methoxynicotinic acid and methylamine hydrochloride (4.3 equiv); 1H NMR (400 MHz, DMSO-d6) δ ppm 8.42 (d, 1 H), 8.26-8.35 (m, 1 H), 8.20 (d, 1 H), 3.95 (s, 3 H), 2.79 (d, 3 H); MS (APPI/APCI) m/z 245, 247[M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143408B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-864177fcde334bedb8cb513a08142e48 |
| Source note | uspto-grants-2012_03 |