(Pyrimidin-5-yl)boronic acid → HCID 25115138, compound

Participants

Reaction Steps

The title compound was synthesized as described for Intermediate example I-2 in 78% yield, starting from 5-pyrimidinylboronic acid and (3S)-3-(dibenzylamino)-3,4-dihydro -2H-chromen-5-yl trifluoromethanesulfonate; 1H NMR (400 MHz, DMSO-d6) δ ppm 9.24 (s, 1 H), 8.86 (s, 2 H), 7.24-7.34 (m, 8 H), 7.15-7.23 (m, 3 H), 6.86 (d, 2 H), 4.32-4.38 (m, 1 H), 4.00-4.08 (m, 1 H), 3.61-3.75 (m, 4 H), 3.05-3.14 (m, 1 H), 2.93-3.03 (m, 1 H), 2.46-2.54 (m, 1 H, obscured by DSMO); MS (ESI) m/z 408[M+H+].

Provenance & Evidence