2-Methoxypyrimidine-5-boronic acid → HCID 25116059, compound

Participants

Reaction Steps

The title compound was synthesized as described for Intermediate example I-4 in 80% yield starting from (S)-N,N-dibenzyl-8-bromo-1,2,3,4-tetrahydronaphthalen-2-amine and 2-methoxypyrimidine-5-boronic acid (1.9 equiv) and. The reaction mixture was irradiated in a microwave under an atmosphere of argon at 140° C. for 1 h; 1H NMR (400 MHz, DMSO-d6) δ ppm 8.59 (s, 2 H), 7.22-7.32 (m, 8 H), 7.09-7.20 (m, 4 H), 7.00-7.04 (m, 1 H), 4.00 (s, 3 H), 3.53-3.70 (m, 4 H), 2.87-3.00 (m, 2 H), 2.64-2.85 (m, 2 H), 2.45-2.54 (m, 1 H, obscured by DMSO), 2.05-2.14 (m, 1 H), 1.62-1.78 (m, 1 H); MS (ESI) m/z 436[M+H+].

Provenance & Evidence