HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1099427Generated: October 31, 2026
Lithium Hydroxide → 6-(2-methylpropoxy)pyridine-3-carboxylic acid
https://huagongshe.com/reaction/1099427
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Ethyl 6-chloronicotinate | HCID 2799611 | — |
| Reactant | 6-Ethoxypyridine-3-carboxylic acid | HCID 6485817 | — |
| Solvent | Isobutanol | HCID 6560 | — |
| Product | 6-(2-methylpropoxy)pyridine-3-carboxylic acid | HCID 20120861 | 25% |
Reaction Steps
The title compound was synthesized as described for Intermediate example I-81 in 25% yield starting from ethyl 6-chloronicotinate and 2-methylpropan-1-ol. The reduction was performed using 3 equiv of lithium hydroxide, the reaction mixture was stirred at 35° C. over night. The product contains 58% of 6-ethoxynicotinic acid; MS (ESI) m/z 194[M−H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08143408B2 |
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| Source dataset | uspto-grants-2012_03 |
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| ORD ID | ord-06a93e42733d453585c5cb7252fc5f95 |
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| Source note | uspto-grants-2012_03 |
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