Lithium Hydroxide → 1072855-43-6

Participants

Reaction Steps

The title compound was synthesized as described for Intermediate example I-81 in 32% yield starting from methyl 2-chloropyrimidine-5-carboxylate and cyclopentanol. The reduction was performed using 3 equiv of lithium hydroxide, the reaction mixture was stirred at ambient temperature over night; 1H NMR (400 MHz, DMSO-d6) δ ppm 8.99 (s, 2 H), 5.38-5.48 (m, 1 H), 1.89-2.04 (m, 2 H), 1.67-1.83 (m, 4 H), 1.55-1.67 (m, 2 H); MS (ESI) m/z 207[M−H+].

Provenance & Evidence