反应详情

A solution of methyl 6-[(3,3,3-trifluoropropyl)carbamoyl]nicotinate (0.265 g, 0.96 mmol), sodium hydroxide (9.60 ml, 9.60 mmol), and ethanol (10 mL) was heated to 50° C. for 3.5 h. The volatiles were removed in vacuo. The residue was suspended in water (20 mL) and insoluble material was filtered off. The filtrate was cooled on ice and 6 M hydrochloric acid was added while stirring until an acidic pH was reached. The precipitate was filtered off, washed with ice-water and dried in vacuo to yield 78 mg (31%); MS (APPI/APCI) m/z 263[M+H+].

1. customThe volatiles were removed in vacuo
2. filtrationinsoluble material was filtered off
3. temperatureThe filtrate was cooled on ice and 6 M hydrochloric acid
4. additionwas added
5. filtrationThe precipitate was filtered off
6. washwashed with ice-water
7. customdried in vacuo
8. customto yield 78 mg (31%)