Lithium hydroxide, monohydrate → HCID 59354911, compound

Participants

Reaction Steps

To methyl 6-(methyl(2,2,2-trifluoroethyl)carbamoyl)nicotinate (425 mg, 1.54 mmol) in tetrahydrofuran (17 mL) and water (8.5 mL) was lithium hydroxide monohydrate (193 mg, 4.60 mmol) added and the reaction mixture was stirred at ambient temperature over night. The organic solvent was evaporated, 1M hydrochloric acid added until an acidic pH was reached followed by extraction with ethyl acetate (3×25 mL). The organic layer was dried over sodium sulfate and concentrated in vacuo to yield 366 mg (91%) of the title compound as a solid; MS (APPI/APCI) m/z 263[M+H+].

Provenance & Evidence