1,3-Thiazol-2-ylmethanol → HCID 59354922, compound

Participants

Reaction Conditions

Reaction Steps

The title compound was synthesized as described for Intermediate example I-81 in 21% yield starting from ethyl 6-chloronicotinate and 1,3-thiazol-2-ylmethanol. The deprotonation step was performed at ambient temperature and the intermediate product was purified by column chromatography using a gradient of ethyl acetate in heptane. The reduction step was carried out in sodium hydroxide:ethanol 50/50 heated to 50° C. for 1.5 h; 1H NMR (400 MHz, DMSO-d6) δ ppm 8.74 (d, 1 H), 8.21 (dd, 1 H), 7.83 (d, 1 H), 7.76 (d, 1 H), 7.04 (d, 1 H), 5.74 (s, 2 H); MS (APPI/APCI) m/z 237[M+H+].

Provenance & Evidence