2-Butyn-1-ol → HCID 23020169, compound

HRID 1099456Notes

Reaction equation

HRID 1099456 reaction equation
Cl[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[CH:4][N:3]=1.[CH2:13]([OH:17])[C:14]#[C:15][CH3:16]>>[CH2:13]([O:17][C:2]1[CH:12]=[CH:11][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1)[C:14]#[C:15][CH3:16]

Participants

3

Reactant 2

HCID 129912-Butyn-1-olHCID 2799611Ethyl 6-chloronicotinate

Product 1

HCID 23020169HCID 23020169, compoundYield 38%

Procedure

The title compound was synthesized as described for Intermediate example I-92 in 38% yield starting from ethyl 6-chloronicotinate and 2-butyn-1-ol; 1H NMR (400 MHz, DMSO-d6) δ ppm 8.61-8.76 (m, 1 H), 8.03-8.23 (m, 1 H), 6.83-6.98 (m, 1 H), 4.94-5.05 (m, 2 H), 1.74-1.91 (m, 3 H); MS (ESI) m/z 192[M+H+], m/z 190[M−H+].

Sources & evidence

ORD record
ord-64db59f416f241e28bb0c8c2fb315142
Source dataset
uspto-grants-2012_03
Patent number
US08143408B2

Reaction notes

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