Sodium Hydroxide → HCID 178467362, compound

Participants

Reaction Conditions

Reaction Steps

In the second step candesartan methyl ester is added to NaOH solution and is stirred for 1-2 hr at 68-72° C. The solution is cooled and washed twice with dichloromethane and once with toluene. To the aqueous solution is added methanol and the solution pH is adjusted to 7.9±0.5 with conc. HCl. The solution is stirred at 25±5° C. for one hr which is added to water and the pH is adjusted to 3.5±0.3 with conc. HCl. The reaction mixture is diluted with water and cooled to 10° C. or less and the product candesartan formed is washed with acetone and dried.

Provenance & Evidence