反应详情

In a reactor, 1 g of the compound obtained in Step A is introduced into 30 ml of acetonitrile, and there are then added 4.39 g of propylphosphonic anhydride and 438 mg of NH4Cl and, at the end of the addition, 3.8 ml of diisopropylamine at ambient temperature. The solution is stirred for 4 hours under nitrogen, the solvents are then evaporated off, the residue is taken up in saturated aqueous NaCl solution, and extraction with ethyl acetate is carried out. The solvents are then dried over Na2SO4 and then evaporated off to yield the title product in the form of an orange solid in a yield of 80% and with a chemical purity of 90%.

1. customthe solvents are then evaporated off
2. extractionextraction with ethyl acetate
3. dry with materialThe solvents are then dried over Na2SO4
4. customevaporated off