(S)-benzyl 3-cyclobutyl-2-(dibenzylamino)propanoate → (S)-3-cyclobutyl-2-(dibenzylamino)propanoic acid

HRID 1099509Notes

Reaction equation

HRID 1099509 reaction equation
[CH:1]1([CH2:5][C@H:6]([N:17]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:7]([O:9]CC2C=CC=CC=2)=[O:8])[CH2:4][CH2:3][CH2:2]1.C(N(CC1C=CC=CC=1)[C@@H](CC)C(O)=O)C1C=CC=CC=1>>[CH:1]1([CH2:5][C@H:6]([N:17]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:7]([OH:9])=[O:8])[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 58012836(S)-benzyl 3-cyclobutyl-2-(dibenzylamino)propanoateHCID 60075691(S)-2-(dibenzylamino)butanoic acid

Product 1

HCID 58012835(S)-3-cyclobutyl-2-(dibenzylamino)propanoic acid

Procedure

Similarly, following the procedure of Example 2A, but replacing (S)-benzyl 2-(dibenzylamino)pentanoate with (S)-benzyl 3-cyclobutyl-2-(dibenzylamino)propanoate, (S)-2-(dibenzylamino)butanoic acid is prepared.

Workup

  1. customis prepared

Sources & evidence

ORD record
ord-938cf7d2fa344109bd5afdc2bff54509
Source dataset
uspto-grants-2012_03
Patent number
US08143448B2

Reaction notes

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