(2S,3S)-1-(cyclopropylamino)-3-(dibenzylamino)-1-oxopentan-2-yl acetate → (2S,3S)-1-(cyclopropylamino)-3-(dibenzylamino)-1-oxohexan-2-yl acetate

HRID 1099513Notes

Reaction equation

HRID 1099513 reaction equation
[CH2:1](N(CC1C=CC=CC=1)[C@@H](CC)C=O)C1C=CC=CC=1.[C:21]([O:24][C@@H:25]([C@@H:32]([N:35]([CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)[CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)[CH2:33][CH3:34])[C:26]([NH:28][CH:29]1[CH2:31][CH2:30]1)=[O:27])(=[O:23])[CH3:22]>>[C:21]([O:24][C@@H:25]([C@@H:32]([N:35]([CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)[CH2:43][C:44]1[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=1)[CH2:33][CH2:34][CH3:1])[C:26]([NH:28][CH:29]1[CH2:31][CH2:30]1)=[O:27])(=[O:23])[CH3:22]

Participants

3

Reactant 2

HCID 44594156(2S,3S)-1-(cyclopropylamino)-3-(dibenzylamino)-1-oxopentan-2-yl acetateHCID 57433110(S)-2-(dibenzylamino)butanal

Product 1

HCID 44594157(2S,3S)-1-(cyclopropylamino)-3-(dibenzylamino)-1-oxohexan-2-yl acetate

Procedure

Similarly, following the procedure of Example 5A, but replacing (S)-2-(dibenzylamino)pentanal with (S)-2-(dibenzylamino)butanal, (2S,3S)-1-(cyclopropylamino)-3-(dibenzylamino)-1-oxopentan-2-yl acetate is prepared.

Workup

  1. customis prepared

Sources & evidence

ORD record
ord-f1a5d2b59afd4239abdb1bed45895f72
Source dataset
uspto-grants-2012_03
Patent number
US08143448B2

Reaction notes

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