反应详情

温度

22.5 °C

Voriconazole (1R)-(−)-10-camphorsulfonate (1 g, 1.72 mmol) was suspended in deionised water (10 ml) and treated with 5 N NaOH (0.34 ml, 1.72 mmol) at 45-55° C. for 2 hours and 30 minutes. The suspension was cooled down to 20-25° C., stirred for 15 minutes and filtered. The cake was washed with deionised water (15 ml). The solid was dried at 50-60° C. under vacuum until constant weight (0.523 g, 87.22% yield).

1. filtrationfiltered
2. washThe cake was washed with deionised water (15 ml)
3. customThe solid was dried at 50-60° C. under vacuum until constant weight (0.523 g, 87.22% yield)