反应详情

温度

22.5 °C

Voriconazole (1R)-(−)-10-camphorsulfonate (1 g, 1.72 mmol, enantiomeric purity 97.18%) was suspended in deionised water (10 ml) and treated with aqueous 10% w/v Na2CO3 (1.82 ml, 1.72 mmol) at 45-55° C. for 2 hours and 30 minutes. The suspension was cooled down to 20-25° C., stirred for 10 minutes and filtered. The cake was washed with deionised water (2×10 ml). The solid was dried at 50-55° C. under vacuum until constant weight (0.48 g, 79.92% yield).

1. additiontreated with aqueous 10%
2. customat 45-55° C.
3. customfor 2 hours
4. custom30 minutes
5. filtrationfiltered
6. washThe cake was washed with deionised water (2×10 ml)
7. customThe solid was dried at 50-55° C. under vacuum until constant weight (0.48 g, 79.92% yield)