Sodium Carbonate → Voriconazole

Participants

Reaction Conditions

Reaction Steps

Voriconazole (1R)-(−)-10-camphorsulfonate (4 g, 6.88 mmol, enantiomeric purity 98.52) was suspended in deionised water (40 ml) and treated with aqueous 10% w/v Na2CO3 (7.29 ml, 6.88 mmol) at 45-55° C. for 2 hours and 30 minutes. The suspension was cooled down to 20-25° C., stirred for 15 minutes and filtered. The cake was washed with deionised water (2×10 ml). The solid was dried at 50-60° C. under vacuum until constant weight (2.2 g, 91.67% yield).

Provenance & Evidence