Sodium Carbonate → Voriconazole

Participants

Reaction Conditions

Reaction Steps

Voriconazole (1R)-(−)-10-camphorsulfonate from example 12 (11 g, 18.9 mmol, enantiomeric purity 100%) was suspended in deionised water (110 ml) and treated with aqueous 10% w/v Na2CO3 (20.4 ml, 18.9 mmol) at 45-55° C. for 2 hours and 30 minutes. The suspension was cooled down to 20-25° C. and filtered. The cake was washed with deionised water (2×20 ml). The solid was dried at 50-60° C. under vacuum until constant weight (6.18 g, 93.49% yield).

Provenance & Evidence