N-2',4',6'-Trimethoxyphenacyl bromide → HCID 57693765, compound

HRID 1099532Notes

Reaction equation

HRID 1099532 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][SH:10])=[CH:5][C:4]=1[N+:11]([O-:13])=[O:12].Br[CH2:15][C:16]([C:18]1[C:23]([O:24][CH3:25])=[CH:22][C:21]([O:26][CH3:27])=[CH:20][C:19]=1[O:28][CH3:29])=[O:17]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][S:10][CH2:15][C:16]([C:18]2[C:19]([O:28][CH3:29])=[CH:20][C:21]([O:26][CH3:27])=[CH:22][C:23]=2[O:24][CH3:25])=[O:17])=[CH:5][C:4]=1[N+:11]([O-:13])=[O:12]

Participants

3

Reactant 2

HCID 193915N-2',4',6'-Trimethoxyphenacyl bromideHCID 54578299HCID 54578299, compound

Product 1

HCID 57693765HCID 57693765, compound

Procedure

According to Scheme 5, (4-methoxy-3-nitrophenyl)methanethiol 10 (an aromatic mercaptan according to Formula IIb) is reacted with 2-bromo-1-(2,4,6-trimethoxyphenyl)ethanone (a compound according to Formula IIa) to form 2-(4-methoxy-3-nitrobenzylthio)-1-(2,4,6-trimethoxyphenyl)ethanone 11 (a sulfide according to Formula II). Suitable reaction conditions for this reaction are as described above for the reaction of a Formula IIa compound and a Formula IIb compound.

Sources & evidence

ORD record
ord-06be1d5d419842b0848f791af9d883a0
Source dataset
uspto-grants-2012_03
Patent number
US08143453B2

Reaction notes

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