Hydrochloric Acid → HCID 57710193, compound

Participants

Reaction Steps

200 g of 1-Bromoheptane were slowly added at 65° C. to a suspension of 32.6 g of magnesium, 0.5 g of iodine and 2.4 ml of Dibromoetane in a mixture of 182 ml of THF and 400 ml of toluene. The reaction mixture was stirred at the same temperature for 3 h. When the formation of the corresponding Grignard compound was completed, the mixture was cooled down at room temperature and a solution of 158 g of Oxazolidine (II) in 500 ml of toluene was added in 1 hour. The mixture was stirred for 30 min. and then added to 795 ml solution of aqueous 5% HCl. The organic layer is decanted and concentrated until dryness. Compound (IC) was obtained as an orange oil (179 g). MS (EI), (m/z, %): 229 (M+., 1), 198 (M-CH2OH, 25). 130 (M-C7H15, 100), 112 (M-C7H15-H2O, 4), 100 (M-73, 30), 85 (5 56 (10), 41 (8).

Provenance & Evidence