HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylparaben → N-[4-(3,3,3-Trifluoropropoxy)benzoyl]glycine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylparaben | HCID 7456 | — |
| Reactant | 3,3,3-Trifluoro-1-propanol | HCID 137512 | — |
| Reactant | N-[4-(2-Cyclopropylethoxy)benzoyl]glycine | HCID 66812105 | — |
| Product | N-[4-(3,3,3-Trifluoropropoxy)benzoyl]glycine | HCID 66812639 | 14% |
Reaction Steps
The same reactions as in Example 9 (9a) and (9b) were conducted using methyl 4-hydroxybenzoate (1.52 g, 9.99 mmol) and 3,3,3-trifluoropropan-1-ol (1.14 g, 9.99 mmol) to give 385 mg of the title compound (white powder, yield: 14%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143446B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-ef700115fb074a46b1970b3363a67466 |
| Source note | uspto-grants-2012_03 |