N-(4-Hydroxybenzoyl)glycine tert-butyl ester → HCID 66812079, compound

HRID 1099575Notes

Reaction equation

HRID 1099575 reaction equation
C([O:5][C:6](=[O:18])[CH2:7][NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)(C)(C)C.[CH:19]1([CH2:22][CH2:23][CH2:24][CH2:25]O)[CH2:21][CH2:20]1>>[CH:19]1([CH2:22][CH2:23][CH2:24][CH2:25][O:16][C:13]2[CH:12]=[CH:11][C:10]([C:9]([NH:8][CH2:7][C:6]([OH:5])=[O:18])=[O:17])=[CH:15][CH:14]=2)[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 10682169N-(4-Hydroxybenzoyl)glycine tert-butyl esterHCID 230002215687-83-2

Product 1

HCID 66812079HCID 66812079, compoundYield 88%

Procedure

The same reaction as in Example 1 (1b) was conducted using N-(4-hydroxybenzoyl)glycine tert-butyl ester (251 mg, 1.00 mmol) prepared in Example 1 (1a) and 4-cyclopropylbutan-1-ol (which is the compound disclosed in J. Med. Chem., (1998), 41, 1112-1123, 137 mg, 1.20 mmol) to give 257 mg of the title compound (white powder, yield: 88%).

Sources & evidence

ORD record
ord-db591774a97e4b198292ead87ab0b737
Source dataset
uspto-grants-2012_03
Patent number
US08143446B2

Reaction notes

Loading…