2-Naphthaleneethanol → HCID 66811877, compound

HRID 1099576Notes

Reaction equation

HRID 1099576 reaction equation
C([O:5][C:6](=[O:18])[CH2:7][NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)(C)(C)C.[CH:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][C:20]=1[CH2:29][CH2:30]O>>[CH:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][C:20]=1[CH2:29][CH2:30][O:16][C:13]1[CH:12]=[CH:11][C:10]([C:9]([NH:8][CH2:7][C:6]([OH:5])=[O:18])=[O:17])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 738772-NaphthaleneethanolHCID 10682169N-(4-Hydroxybenzoyl)glycine tert-butyl ester

Product 1

HCID 66811877HCID 66811877, compoundYield 90%

Procedure

The same reaction as in Example 1 (1b) was conducted using N-(4-hydroxybenzoyl)glycine tert-butyl ester (251 mg, 1.00 mmol) prepared in Example 1 (1a) and 2-(2-naphthyl)ethanol (207 mg, 1.20 mmol) to give 314 mg of the title compound (white powder, yield: 90%).

Sources & evidence

ORD record
ord-b14d0ab23d66485a8cabc4c5300eb4f3
Source dataset
uspto-grants-2012_03
Patent number
US08143446B2

Reaction notes

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