HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Fluorophenyl)ethan-1-ol → N-{4-[2-(2-Fluorophenyl)ethoxy]benzoyl}glycine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Fluorophenyl)ethan-1-ol | HCID 2733296 | — |
| Reactant | N-(4-Hydroxybenzoyl)glycine tert-butyl ester | HCID 10682169 | — |
| Product | N-{4-[2-(2-Fluorophenyl)ethoxy]benzoyl}glycine | HCID 66811873 | 73.4% |
Reaction Steps
The same reaction as in Example 1 (1b) was conducted using N-(4-hydroxybenzoyl)glycine tert-butyl ester (231 mg, 0.919 mmol) prepared in Example 1 (1a) and 2-(2-fluorophenyl)ethanol (137 μL, 1.02 mmol) to give 214 mg of the title compound (white powder, yield: 73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143446B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-4bdd2ac5751b4515867509b9b42b8031 |
| Source note | uspto-grants-2012_03 |