4-(2-Hydroxyethyl)benzonitrile → HCID 66812162, compound

HRID 1099579Notes

Reaction equation

HRID 1099579 reaction equation
C([O:5][C:6](=[O:18])[CH2:7][NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)(C)(C)C.O[CH2:20][CH2:21][C:22]1[CH:29]=[CH:28][C:25]([C:26]#[N:27])=[CH:24][CH:23]=1>>[C:26]([C:25]1[CH:28]=[CH:29][C:22]([CH2:21][CH2:20][O:16][C:13]2[CH:12]=[CH:11][C:10]([C:9]([NH:8][CH2:7][C:6]([OH:5])=[O:18])=[O:17])=[CH:15][CH:14]=2)=[CH:23][CH:24]=1)#[N:27]

Participants

3

Reactant 2

HCID 28008154-(2-Hydroxyethyl)benzonitrileHCID 10682169N-(4-Hydroxybenzoyl)glycine tert-butyl ester

Product 1

HCID 66812162HCID 66812162, compoundYield 46%

Procedure

The same reaction as in Example 1 (1b) was conducted using N-(4-hydroxybenzoyl)glycine tert-butyl ester (582 mg, 3.83 mmol) prepared in Example 1 (1a) and 4-(2-hydroxyethyl)benzonitrile (592 mg, 4.02 mmol) to give 226 mg of the title compound (white powder, yield: 46%).

Sources & evidence

ORD record
ord-ef9979d28150491fb942900a90f21f1a
Source dataset
uspto-grants-2012_03
Patent number
US08143446B2

Reaction notes

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