2-(4-isopropoxyphenyl)ethanol → HCID 66812295, compound

HRID 1099582Notes

Reaction equation

HRID 1099582 reaction equation
C([O:3][C:4](=[O:16])[CH2:5][NH:6][C:7](=[O:15])[C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1)C.[CH:17]([O:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH2:28]O)=[CH:23][CH:22]=1)([CH3:19])[CH3:18]>>[CH:17]([O:20][C:21]1[CH:22]=[CH:23][C:24]([CH2:27][CH2:28][O:14][C:11]2[CH:10]=[CH:9][C:8]([C:7]([NH:6][CH2:5][C:4]([OH:3])=[O:16])=[O:15])=[CH:13][CH:12]=2)=[CH:25][CH:26]=1)([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 2280962-(4-isopropoxyphenyl)ethanolHCID 10846723HCID 10846723, compound

Product 1

HCID 66812295HCID 66812295, compoundYield 82%

Procedure

The same reaction as in Example 78 (78a) was conducted using N-(4-hydroxybenzoyl)glycine ethyl ester (which is the compound disclosed in J. Med. Chem., (1999), 42, 1041-1052, 397 mg, 2.20 mmol) and 2-(4-isopropoxyphenyl)ethanol (which is the compound disclosed in J. Chem. Soc. Perkin Trans. 1, (1983), 619-624, 447 mg, 2.00 mmol) to give 636 mg of the title compound (white powder, yield: 82%).

Sources & evidence

ORD record
ord-c137df1b83a14f5da491adaca049bb37
Source dataset
uspto-grants-2012_03
Patent number
US08143446B2

Reaction notes

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