HRID1099694

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID98969

Ethyl nipecotate

C8H15NO2

结构：CCOC(=O)C[S@@](=O)(=NC(=O)c1cncc(C#Cc2cccc(NC(=O)c3occc3C)c2)c1)c1ccccc1

HCID57657941

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)[C@H]1CCCN(C(=O)CS(=O)(=NC(=O)c2cncc(C#Cc3cccc(NC(=O)c4occc4C)c3)c2)c2ccccc2)C1

HCID86629491

未命名化合物

PROCEDURE

实验过程

In a manner similar to that described in Example 534, (S)-Ethyl (N-{[5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)pyridin-3-yl]carbonyl}-S-phenylsulfonimidoyl)acetate and ethyl nipecotate were reacted to give the title compound

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b99229225d84480e99591bc90040a28d
来源数据集: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08143410B2
来源说明: uspto-grants-2012_03

反应 SMILES

[CH3:1][C:2]1[CH:6]=[CH:5][O:4][C:3]=1[C:7]([NH:9][C:10]1[CH:11]=[C:12]([C:16]#[C:17][C:18]2[CH:19]=[C:20]([C:24]([N:26]=[S@:27]([CH2:35][C:36](OCC)=[O:37])([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[O:28])=[O:25])[CH:21]=[N:22][CH:23]=2)[CH:13]=[CH:14][CH:15]=1)=[O:8].[NH:41]1[CH2:51][CH2:50][CH2:49][CH:43]([C:44]([O:46][CH2:47][CH3:48])=[O:45])[CH2:42]1>>[CH3:1][C:2]1[CH:6]=[CH:5][O:4][C:3]=1[C:7]([NH:9][C:10]1[CH:11]=[C:12]([C:16]#[C:17][C:18]2[CH:19]=[C:20]([C:24]([N:26]=[S:27]([CH2:35][C:36]([N:41]3[CH2:51][CH2:50][CH2:49][C@H:43]([C:44]([O:46][CH2:47][CH3:48])=[O:45])[CH2:42]3)=[O:37])([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[O:28])=[O:25])[CH:21]=[N:22][CH:23]=2)[CH:13]=[CH:14][CH:15]=1)=[O:8]