Ethyl nipecotate → (S)-Ethyl 1-[(N-{[5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)pyridin-3-yl]carbonyl}-S-phenylsulfonimidoyl)acetyl]piperidine-3-carboxylate

HRID 1099694Notes

Reaction equation

HRID 1099694 reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][O:4][C:3]=1[C:7]([NH:9][C:10]1[CH:11]=[C:12]([C:16]#[C:17][C:18]2[CH:19]=[C:20]([C:24]([N:26]=[S@:27]([CH2:35][C:36](OCC)=[O:37])([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[O:28])=[O:25])[CH:21]=[N:22][CH:23]=2)[CH:13]=[CH:14][CH:15]=1)=[O:8].[NH:41]1[CH2:51][CH2:50][CH2:49][CH:43]([C:44]([O:46][CH2:47][CH3:48])=[O:45])[CH2:42]1>>[CH3:1][C:2]1[CH:6]=[CH:5][O:4][C:3]=1[C:7]([NH:9][C:10]1[CH:11]=[C:12]([C:16]#[C:17][C:18]2[CH:19]=[C:20]([C:24]([N:26]=[S:27]([CH2:35][C:36]([N:41]3[CH2:51][CH2:50][CH2:49][C@H:43]([C:44]([O:46][CH2:47][CH3:48])=[O:45])[CH2:42]3)=[O:37])([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[O:28])=[O:25])[CH:21]=[N:22][CH:23]=2)[CH:13]=[CH:14][CH:15]=1)=[O:8]

Participants

3

Reactant 2

HCID 98969Ethyl nipecotateHCID 57657941(S)-Ethyl (N-{[5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)pyridin-3-yl]carbonyl}-S-phenylsulfonimidoyl)acetate

Product 1

HCID 86629491(S)-Ethyl 1-[(N-{[5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)pyridin-3-yl]carbonyl}-S-phenylsulfonimidoyl)acetyl]piperidine-3-carboxylate

Procedure

In a manner similar to that described in Example 534, (S)-Ethyl (N-{[5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)pyridin-3-yl]carbonyl}-S-phenylsulfonimidoyl)acetate and ethyl nipecotate were reacted to give the title compound

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b99229225d84480e99591bc90040a28d
Source dataset
uspto-grants-2012_03
Patent number
US08143410B2

Reaction notes

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