HRID1099700

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)Cc1cccc(S(C)(=O)=NC(=O)C(F)(F)F)c1

HCID57657827

未命名化合物

结构：Cc1cc(C(=O)Nc2cccc(C#Cc3cc(C(=O)O)cnc3N)c2)n(C)n1

HCID57657867

未命名化合物

PRODUCTS

生成物

结构：COC(=O)Cc1cccc(S(C)(=O)=NC(=O)c2cnc(N)c(C#Cc3cccc(NC(=O)c4cc(C)nn4C)c3)c2)c1

HCID57657942

未命名化合物

PROCEDURE

实验过程

In a manner similar to that described in Example 496 (step 5), 6-amino-5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]nicotinic acid and methyl {3-[S-methyl-N-(trifluoroacetyl)sulfonimidoyl]phenyl}acetate were reacted to give the title compound

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-968fcea5b28a4e939073ff80838b668b
来源数据集: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08143410B2
来源说明: uspto-grants-2012_03

反应 SMILES

[NH2:1][C:2]1[C:10]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:20]([C:22]3[N:26]([CH3:27])[N:25]=[C:24]([CH3:28])[CH:23]=3)=[O:21])[CH:14]=2)=[CH:9]C(C(O)=O)=[CH:4][N:3]=1.[CH3:29][S:30]([C:39]1[CH:40]=[C:41]([CH2:45][C:46]([O:48][CH3:49])=[O:47])[CH:42]=[CH:43][CH:44]=1)(=[N:32][C:33](=[O:38])[C:34](F)(F)F)=[O:31]>>[NH2:1][C:2]1[N:3]=[CH:4][C:34]([C:33]([N:32]=[S:30]([C:39]2[CH:40]=[C:41]([CH2:45][C:46]([O:48][CH3:49])=[O:47])[CH:42]=[CH:43][CH:44]=2)([CH3:29])=[O:31])=[O:38])=[CH:9][C:10]=1[C:11]#[C:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:20]([C:22]2[N:26]([CH3:27])[N:25]=[C:24]([CH3:28])[CH:23]=2)=[O:21])[CH:14]=1