HCID 66811079, compound → HCID 66811220, compound

HRID 1099704Notes

Reaction equation

HRID 1099704 reaction equation
O[C:2]1[CH:3]=[C:4]([NH:10][S:11]([C:14]2[C:15](=[O:24])[S:16][C:17]3[C:22]([CH:23]=2)=[CH:21][CH:20]=[CH:19][CH:18]=3)(=[O:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].NC1C=C(NS(C2C(=O)SC3C(C=2)=CC=CC=3)(=O)=O)C=CC=1F.BrC1C=CC(NS(C2C(=O)SC3C(C=2)=CC=CC=3)(=O)=O)=CC=1.ClC1C=C2C(C=C(S(NC3C=CC(OC)=CC=3)(=O)=O)C(=O)S2)=CC=1.ClC1C=C2C(C=C(S(NC3C=CC(OC)=C(O)C=3)(=O)=O)C(=O)S2)=CC=1.ClC1C=C2C(C=C(S(NC3C=CC(F)=C(N)C=3)(=O)=O)C(=O)S2)=CC=1.ClC1C=C2C(C=C(S(NC3C=CC(Br)=CC=3)(=O)=O)C(=O)S2)=CC=1.ClC1C=C2C(=CC=1)SC(=O)C(S(NC1C=CC(OC)=CC=1)(=O)=O)=C2.BrC1C=C2C(=CC=1)SC(=O)C(S(NC1C=CC(OC)=CC=1)(=O)=O)=C2.C(OC1C=CC=C2C=1SC(=O)C(S(NC1C=CC(OC)=CC=1)(=O)=O)=C2)C.ClC1C=C2C(=CC=1)SC(=O)C(S(NC1C=CC(OC)=C(O)C=1)(=O)=O)=C2.NC1C=C(NS(C2C(=O)SC3C(C=2)=CC=CC=3OCC)(=O)=O)C=CC=1F.NC1C=C(NS(C2C(=O)SC3C(C=2)=CC(OC)=CC=3)(=O)=O)C=CC=1F.BrC1C=CC(NS(C2C(=O)SC3C(C=2)=CC(OC)=CC=3)(=O)=O)=CC=1.BrC1C=CC(NS(C2C(=O)SC3C(C=2)=CC=CC=3Cl)(=O)=O)=CC=1.BrC1C=CC(NS(C2C(=O)SC3C(C=2)=CC=CC=3Br)(=O)=O)=CC=1>>[CH3:9][O:8][C:7]1[CH:6]=[CH:5][C:4]([NH:10][S:11]([C:14]2[C:15](=[O:24])[S:16][C:17]3[C:22]([CH:23]=2)=[CH:21][CH:20]=[CH:19][CH:18]=3)(=[O:13])=[O:12])=[CH:3][CH:2]=1

Participants

16

Reactant 15

HCID 66811079HCID 66811079, compoundHCID 66811151HCID 66811151, compoundHCID 66811189HCID 66811189, compoundHCID 66811199HCID 66811199, compoundHCID 66811327HCID 66811327, compoundHCID 66811340HCID 66811340, compoundHCID 66811410HCID 66811410, compound2×HCID 66811459HCID 66811459, compoundHCID 66811468HCID 66811468, compoundHCID 66811473HCID 66811473, compoundHCID 66811496HCID 66811496, compoundHCID 66811525HCID 66811525, compoundHCID 66811579HCID 66811579, compoundHCID 66811583HCID 66811583, compoundHCID 66811695HCID 66811695, compound

Product 1

HCID 66811220HCID 66811220, compound

Procedure

N-(3-hydroxy-4-methoxyphenyl)-2-oxo-2H-thiochromene-3-sulfonamide; N-(3-amino-4-fluorophenyl)-2-oxo-2H-thiochromene-3-sulfonamide; N-(4-bromophenyl)-2-oxo-2H-thiochromene-3-sulfonamide; 7-chloro-N-(4-methoxyphenyl)-2-oxo-2H-thiochromene-3-sulfonamide; 7-chloro-N-(3-hydroxy-4-methoxyphenyl)-2-oxo-2H-thiochromene-3-sulfonamide; 7-chloro-N-(3-amino-4-fluorophenyl)-2-oxo-2H-thiochromene-3-sulfonamide; 7-chloro-N-(4-bromophenyl)-2-oxo-2H-thiochromene-3-sulfonamide; 6-bromo-N-(4-methoxyphenyl)-2-oxo-2H-thiochromene-3-sulfonamide 6-chloro-N-(4-methoxyphenyl)-2-oxo-2H-thiochromene-3-sulfonamide; 8-ethoxy-N-(4-methoxyphenyl)-2-oxo-2H-thiochromene-3-sulfonamide; 6-chloro-N-(3-hydroxy-4-methoxyphenyl)-2-oxo-2H-thiochromene-3-sulfonamide; N-(3-amino-4-fluorophenyl)-8-ethoxy-2-oxo-2H-thiochromene-3-sulfonamide; N-(3-amino-4-fluorophenyl)-6-methoxy-2-oxo-2H-thiochromene-3-sulfonamide; N-(4-bromophenyl)-6-methoxy-2-oxo-2H-thiochromene-3-sulfonamide; 8-ethoxy-N-(4-methoxyphenyl)-2-oxo-2H-thiochromene-3-sulfonamide; N-(4-bromo-phenyl)-8-chloro-2-oxo-2H-thiochromene-3-sulfonamide; N-(4-bromophenyl)-8-bromo-2-oxo-2H-thiochromene-3-sulfonamide; mixtures thereof; and salts thereof.

Sources & evidence

ORD record
ord-43e8e82dc5c34914b0528ca3eb0cae91
Source dataset
uspto-grants-2012_03
Patent number
US08143428B2

Reaction notes

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