5-Chloro-salicylaldehyde → 6-chloro-N-(3-hydroxy-4-methoxyphenyl)-2-oxo-2H-chromene-3-sulfonamide

HRID 1099708Notes

Reaction equation

HRID 1099708 reaction equation
[Cl:1][C:2]1[CH:9]=[C:6]([CH:7]=O)[C:5]([OH:10])=[CH:4][CH:3]=1.[OH:11][C:12]1[CH:13]=[C:14]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[NH:15][S:16]([CH2:19][C:20](O)=[O:21])(=[O:18])=[O:17]>C(O)(=O)C>[Cl:1][C:2]1[CH:9]=[C:6]2[C:5](=[CH:4][CH:3]=1)[O:10][C:20](=[O:21])[C:19]([S:16]([NH:15][C:14]1[CH:23]=[CH:24][C:25]([O:26][CH3:27])=[C:12]([OH:11])[CH:13]=1)(=[O:17])=[O:18])=[CH:7]2

Participants

4

Reactant 2

HCID 124815-Chloro-salicylaldehydeHCID 437148443-Hydroxy-4-methoxyanilinosulfonyl acetic acid

Product 1

HCID 117036296-chloro-N-(3-hydroxy-4-methoxyphenyl)-2-oxo-2H-chromene-3-sulfonamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 5-chlorosalicylaldehyde (1 mmol) and 3-hydroxy-4-methoxyanilinosulfonyl acetic acid (1 mmol) in acetic acid (10 mL) was subjected to the General Procedure 1, Method A to yield the title compound; m.p. 225-226° C.

Sources & evidence

ORD record
ord-5d71edee3d6b438997de147fb656f520
Source dataset
uspto-grants-2012_03
Patent number
US08143428B2

Reaction notes

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