O-Ethylvanillin → N-(3-amino-4-fluorophenyl)-8-ethoxy-2-oxo-2H-chromene-3-sulfonamide

HRID 1099709Notes

Reaction equation

HRID 1099709 reaction equation
[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][CH:9]=[C:6]([CH:7]=O)[C:5]=1[OH:12])[CH3:2].[NH2:13][C:14]1[CH:15]=[C:16]([CH:25]=[CH:26][C:27]=1[F:28])[NH:17][S:18]([CH2:21][C:22](O)=[O:23])(=[O:20])=[O:19]>C(O)(=O)C>[NH2:13][C:14]1[CH:15]=[C:16]([NH:17][S:18]([C:21]2[C:22](=[O:23])[O:12][C:5]3[C:6]([CH:7]=2)=[CH:9][CH:10]=[CH:11][C:4]=3[O:3][CH2:1][CH3:2])(=[O:20])=[O:19])[CH:25]=[CH:26][C:27]=1[F:28]

Participants

4

Reactant 2

HCID 68117O-EthylvanillinHCID 613575983-Amino-4-fluoroanilinosulfonyl acetic acid

Product 1

HCID 11667998N-(3-amino-4-fluorophenyl)-8-ethoxy-2-oxo-2H-chromene-3-sulfonamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 3-ethoxysalicylaldehyde (1 mmol) and 3-amino-4-fluoroanilinosulfonyl acetic acid (1 mmol) in acetic acid (10 mL) was subjected to the General Procedure 1, Method A to yield the title compound; m.p. 160-162° C.

Sources & evidence

ORD record
ord-70b5f49a4c8845969920363ee59f8ba2
Source dataset
uspto-grants-2012_03
Patent number
US08143428B2

Reaction notes

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